Dimeric structure of p300/CBP associated factor
نویسندگان
چکیده
منابع مشابه
The dimeric structure of factor XI and zymogen activation.
Factor XI (fXI) is a homodimeric zymogen that is converted to a protease with 1 (1/2-fXIa) or 2 (fXIa) active subunits by factor XIIa (fXIIa) or thrombin. It has been proposed that the dimeric structure is required for normal fXI activation. Consistent with this premise, fXI monomers do not reconstitute fXI-deficient mice in a fXIIa-dependent thrombosis model. FXI activation by fXIIa or thrombi...
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The understanding of protein-protein interactions is a major goal in the postgenomic era. The prediction of interaction from sequence and the subsequent generation of full-length dimeric models is therefore of great interest especially because the number of structurally characterized protein-protein complexes is sparse. A quality assessment of a benchmark comprised of 170 weakly homologous dime...
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ژورنال
عنوان ژورنال: BMC Structural Biology
سال: 2014
ISSN: 1472-6807
DOI: 10.1186/1472-6807-14-2